A comparative evaluation of diclofenac sodium transdermal patch, oral diclofenac sodium with intramuscular injections of diclofenac sodium in patients suffering from oral pain: A randomized control trial

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A comparative evaluation of diclofenac sodium transdermal patch, oral diclofenac sodium with intramuscular injections of diclofenac sodium in patients suffering from oral pain: A randomized control trial

Background Newer drug delivery systems such as transdermal patches using pain relieving or modifying agents emerged as a mainstream treatment protocol for management of pain on the outpatient basis. The administration of diclofenac 100 mg in the transdermal patch in the patients having dental pain due to periapical/periodontal infections was evaluated. Materials and Methods Ninety patients of...

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Objectives: The treatment of pain after surgery is central to the care of postoperative patients. Non-steroidal anti-inflammatory drugs are devoid of side effects of opioids like respiratory depression, vomiting, cardiac depression etc. Ketoprofen, a nonsteroidal anti-inflammatory drug, being in use since 1974, is not a much-studied drug. We decided to compare Ketoprofen and Diclofenac sodium f...

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Biowaiver monographs for immediate release solid oral dosage forms: diclofenac sodium and diclofenac potassium.

Literature data are reviewed regarding the scientific advisability of allowing a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing either diclofenac potassium and diclofenac sodium. Within the biopharmaceutics classification system (BCS), diclofenac potassium and diclofenac sodium are each BCS class II active pharmaceutic...

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Effectiveness of Diclofenac Sodium Suppository in Reduction of Pain and Dosage of Fentanyl in Patients Undergoing Colonoscopy: A Randomized Clinical Trial

Background and purpose: Opioid analgesics cause bradycardia and respiratory depression.  The aim of this study was to investigate the efficacy of diclofenac suppository on pain and dose reduction of injectable fentanyl in patients undergoing colonoscopy. Materials and methods: In a clinical trial, 500 patients undergoing colonoscopy were randomly divided into two groups to receive either diclo...

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Diclofenac sodium in biliary colic: a double blind trial.

We studied 30 consecutive outpatients (14 men and 16 women; mean (SD) age 46 (11-8) years) with gallstone disease, confirmed by ultrasonography or radiography or at operation, who complained of biliary colic. Patients were randomly treated under double blind conditions with either 75 mg diclofenac sodium given intramuscularly or placebo and were followed up for 24 hours. All patients had given ...

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ژورنال

عنوان ژورنال: International Journal of Pharmaceutical Investigation

سال: 2017

ISSN: 2230-973X

DOI: 10.4103/jphi.jphi_52_17